About the conference

The Frankfurt Cancer Conference is a meeting of internationally leading cancer researchers as well as junior scientists and oncologists. It was first held in 2018 and is planned as an bi-annual conference.

The main theme of the second Frankfurt Cancer Conference in September 2020 is “From Molecular Research to Mechanism-based Cancer Therapy”. The ongoing translational research activities of the University Cancer Center Frankfurt (UCT), the German Cancer Consortium (DKTK) in Frankfurt/Mainz, the Frankfurt Cancer Institute (FCI) and the Mildred Scheel Career Center (MSNZ) provide the framework for the conference, during which international, national and local research activities will be presented in two poster exhibitions and eight interdisciplinary sessions on the following topics:

  • Tumor Microenvironment & Inflammation
  • Tumor Heterogeneity & Metastasis
  • Cancer Stem Cells & Cell Plasticity
  • Cancer Metabolism & Autophagy
  • Precision Oncology & Tumor Models
  • Target Discovery in Cancer & Drug Development
  • Leukemia & Lymphoma
  • Personalized Oncology: Checkpoint-inhibition & Beyond

Target audience

The conference adresses basic and translational cancer researchers as well as oncologists who are interested in cancer signaling, novel cancer therapies and mechanism-based clinical trials. We want to encourage both early-career as well as established medical and clinician scientists in oncology to participate and present their work to the international community. There will be plenty of opportunities to interact with some of the top experts in the field of cancer research and to establish or deepen collaborations in an inspiring atmosphere.

Scientific Organizing Committee

Prof. Dr. Thomas Oellerich
Chair of Scientific Organizing Committee

Department of Medicine, Hematology/Oncology 
Goethe University Frankfurt
German Cancer Consortium (DKTK) Frankfurt/Mainz

Prof. Dr. Christian Brandts
Co-Chair of Scientific Organizing Committee

Department of Medicine, Hematology/Oncology
University Cancer Center (UCT) Frankfurt
Goethe University Frankfurt
German Cancer Consortium (DKTK) Frankfurt/Mainz

Prof. Dr. Ivan Dikic
Institute of Biochemistry II
Buchmann Institute for Molecular Life Sciences
University Cancer Center (UCT) Frankfurt
Goethe University Frankfurt
German Cancer Consortium (DKTK) Frankfurt/Mainz

Prof. Dr. Simone Fulda
Institute for Experimental Tumor Research in Pediatrics
University Cancer Center (UCT) Frankfurt 
Goethe University Frankfurt 
German Cancer Consortium (DKTK) Frankfurt/Mainz

Prof. Dr. Florian Greten
Institute for Tumor Biology and Experimental Therapy (Georg-Speyer-Haus)
University Cancer Center (UCT) Frankfurt 
Goethe University Frankfurt
German Cancer Consortium (DKTK) Frankfurt/Mainz

Prof. Dr. Stefan Knapp
Institute for Pharmaceutical Chemistry
Goethe University Frankfurt
German Cancer Consortium (DKTK) Frankfurt/Mainz

Prof. Dr. Karlheinz Plate
Institute for Neurology (Edinger Institute)
University Cancer Center (UCT) Frankfurt 
Goethe University Frankfurt
German Cancer Consortium (DKTK) Frankfurt/Mainz

Prof. Dr. Claus Rödel
Department of Radiation Therapy and Oncology
University Cancer Center (UCT) Frankfurt 
Goethe University Frankfurt
German Cancer Consortium (DKTK) Frankfurt/Mainz

Prof. Dr. Hubert Serve
Department of Medicine, Hematology/Oncology
University Cancer Center (UCT) Frankfurt
Goethe University Frankfurt
German Cancer Consortium (DKTK) and DKFZ

Prof. Dr. Joachim Steinbach
Dr. Senckenberg Institute of Neurooncology
University Cancer Cancer (UCT) Frankfurt
Goethe University Frankfurt
German Cancer Consortium (DKTK) Frankfurt/Mainz

Prof. Dr. Peter Wild
Senckenberg Institute of Pathology
University Cancer Cancer (UCT) Frankfurt
Goethe University Frankfurt
German Cancer Consortium (DKTK) Frankfurt/Mainz

Dr. Fabian Finkelmeier
Junior Representative

Department of Medicine, Gastroenterology/Pneumology/Endocrinology
Goethe University Frankfurt
German Cancer Consortium (DKTK) Frankfurt/Mainz

Dr. Manuel Kaulich
Junior Representative

Institute of Biochemistry II
Goethe University Frankfurt
German Cancer Consortium (DKTK) Frankfurt/Mainz

Dr. Lisa Sevenich
Junior Representative

Institute for Tumor Biology and Experimental Therapy (Georg-Speyer-Haus)
Goethe University Frankfurt
German Cancer Consortium (DKTK) Frankfurt/Mainz

Speakers

Scott Armstrong
Dana-Farber Cancer Institute
Harvard Medical School
Boston, USA

Mariano Barbacid
Centro Nacional de Investigaciones Oncológicas
Madrid, ES

Florian Bassermann
Department of Medicine, Hematology/Oncology
Technical University of Munich
Munich, DE

Cédric Blanpain
VIB-KU Leuven Center for Cancer Biology
Vlaams Instituut voor Biotechnologie
Leuven, BE

Peter Carmeliet
VIB-KU Leuven Center for Cancer Biology
Vlaams Instituut voor Biotechnologie
Leuven, BE

Benjamin L. Ebert
Dana-Farber Cancer Institute
Harvard Medical School
Boston, USA

Gerard Evan
Department of Biochemistry
University of Cambridge
Cambridge, UK

Tony Green
Cancer Research UK Cambridge Center
University of Cambridge
Cambridge, UK

Markus Müschen
Beckman Research Institute of City of Hope
Duarte, USA

Jürgen Ruland
Institute for Clinical Chemistry and Pathobiochemistry
Technical University Munich
Munich, DE

Louis M. Staudt
National Cancer Institute
National Institute of Health
Bethesda, USA

Jacco van Rheenen
Netherlands Cancer Institute
Amsterdam, NL

Robert A. Weinberg
Whitehead Institute for Biomedical Research
Massachusetts Institute of Technology
Cambridge, USA

Eileen White
Rutgers Cancer Institute of New Jersey
New Brunswick, USA

Tuesday, 25 September 2018

16:00-18:00 Arrival & Registration (Foyer)
18:00-18:30 Welcome & Introduction: Christian Brandts, University Cancer Center, Frankfurt, DE
18:30-19:30 Opening Session
Session Chairs: Ivan Dikic, Florian Greten
18:30-18:55 Tak W. Mak, University of Toronto, CA:
Targeting genomic instability in cancer: dream or reality
19:00-19:25 René Bernards, Netherlands Cancer Institute, Amsterdam, NL:
A one-two punch model for cancer therapy
19:30 Welcome Reception (Foyer)

 

Wednesday, 26 September 2018

08:30-09:00 Registration (Foyer)
09:00-10:45 Session 1: From cancer stem cells to tumor heterogeneity and treatment resistance
Session Chairs: Daniela Krause, Richard Marais
09:00-09:25 Sean Morrison, University of Texas Southwestern, Dallas, US:
The metabolic regulation of cancer progression
09:30-09:55 Priscilla K. Brastianos, Harvard Medical School, Boston, US:
Genomic evolution of brain metastases
10:00-10:25 Andreas Trumpp, German Cancer Research Center, Heidelberg, DE:
Stem cell features in cancer and therapy resistance
10:30-10:40 Anna Lorentzen, Aarhus University, Aarhus, DK:
Liquid-phase single-cell polarity facilitates tumor cell attachment, adhesion and metastasis
10:45-11:15 Coffee Break (Foyer)
11:15-13:00 Session 2: Novel approaches for improved precision oncology
Session Chairs: René Bernards, Simone Fulda
11:15-11:40 Jürgen Ruland, Technical University Munich, DE:
Antigen receptor and co-receptor signaling pathways in lymphoma: the dark side
11:45-11:55 Birgitta E. Michels, Georg-Speyer-Haus, Frankfurt, DE:
Unbiased identification of tumor suppressor function by pooled CRISPR/Cas9 screening in human colon organoids 
12:00-12:10 Kivanc Görgülü, Technical University Munich, DE:
Levels of Autophagy-related gene (Atg5) determine pancreatic tumor formation and metastasis in mice
12:15-12:40 Lars Zender, University Hospital Tübingen, DE:
Translating cancer biology: from functional target discovery to academic drug discovery and development
12:45-12:55 Simon Kreutzfeldt, National Center for Tumor Diseases, Heidelberg, DE:
Integration of comprehensive molecular profiling into clinical practice
13:00-14:00 Lunch Break (Mensa)
14:00-16:15 Session 3: From oncogenic signaling to targeting pathways
Session Chairs: Laura Soucek, Peter Wild
14:00-14:10 Markus Morkel, Charité - Universitätsmedizin, Berlin, DE:
Cell type-dependent differential activation of ERK by oncogenic KRAS or BRAF in the mouse intestinal epithelium
14:15-14:40 Stefan Pfister, National Center for Tumor Diseases, Heidelberg, DE:
Novel molecular targets in childhood brain tumors
14:45-15:10 Richard Marais, Cancer Research UK Manchester Institute, UK:
Lysyl oxidase regulates tumor cellularity
15:15-15:40 Ivan Dikic, Goethe University Frankfurt, DE:
Ubiquitin networks in cancer pathogenesis
15:45-16:10 Bernhard Küster, Technical University Munich, DE:
The target landscape of clinical kinase drugs
16:15-16:45 Coffee Break (Foyer)
16:45-18:30 Session 4: Cancer metabolism: from understanding to intervention
Session Chairs: Rolf Marschalek, Joachim Steinbach
16:45-17:10 Simone Niclou, Luxembourg Institute of Health, LU:
Harnessing metabolic specificities of IDH mutant glioma for novel therapies
17:15-17:25 Dietrich A. Ruess, Technical University Munich, DE:
Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase
17:30-17:55 Matthew Vander Heiden, Massachusetts Institute of Technology, Cambridge, US:
Considerations to target metabolism for cancer therapy
18:00-18:25 Karen Vousden, The Francis Crick Institute, London, UK:
p53 pathways and cancer cell metabolism
18:30-20:00 Poster Session I
& Finger Food (Foyer and Seminar Rooms First Floor)

 

Thursday, 27 September 2018

08:30-09:00 Registration (Foyer)
09:00-10:45 Session 5: Tumor microenvironment and metastasis
Session Chairs: Claus Rödel, Kimberly Stegmaier
09:00-09:25 Michael Karin, University of California San Diego, US:
Metabolic and immune control of liver tumorigenesis
09:30-09:55 Florian Greten, Georg-Speyer-Haus, Frankfurt, DE:
Modeling colorectal cancer progression
10:00-10:25 Raghu Kalluri, University of Texas, Houston, US:
Functional contribution of tumor microenvironment and exosomes in the biology and treatment of pancreatic cancer
10:30-10:40 Ramona Schulz-Heddergott, University Medical Center Göttingen, DE:
Therapeutic ablation of stabilized gain-of-function mutant p53 in colorectal cancer inhibits Stat3-mediated tumor growth and invasion
10:45-11:15 Coffee Break (Foyer)
11:15-12:45 Session 6: Immunotherapy beyond checkpoint-inhibition
Session Chairs: Bernhard Brüne, Tak W. Mak
11:15-11:40 Michael Platten, University Heidelberg, DE:
Challenges in brain tumor immunotherapy
11:45-11:55 Fabian Coscia, University of Copenhagen, DK:
Multi-level proteomics identifies a novel mediator of chemosensitivity and immunotherapy target in ovarian cancer
12:00-12:10 Emmanouil Fokas, Goethe University Frankfurt, DE:
The stromal immune contexture of pancreatic ductal adenocarcinomaand rationale for combination of radiotherapy with immunotherapy
12:15-12:25 Frederic B. Thalheimer, Paul-Ehrlich-Institute, Langen, DE:
In vivo generation of human CD19-CAR T cells results in B cell depletion and signs of cytokine release syndrome
12:30-12:55 Uğur Şahin, TRON - Translational Oncology a the University Medical Center Mainz, DE:
Personalized cancer immunotherapy
13:00-14:30 Poster Session II
& Lunch (Foyer and Seminar Rooms First Floor)
14:30-16:30 Session 7: Target discovery in cancer
Session Chairs: Hubert Serve, Karen Vousden
14:30-14:40 Svenja Wiechmann, Goethe University Frankfurt, DE:
Targeting Ras interactions: engineered Ras-binding domains as potent competitive inhibitors of oncogenic Ras
14:45-14:55 Manuel Kaulich, Goethe University Frankfurt, DE:
High-fidelity multiplexed CRISPR/Cas libraries for functional interrogations
15:00-15:25 Kimberly Stegmaier, Dana-Farber Cancer Institute, Boston, US:
Identification of new cancer vulnerabilities with functional genomic screens
15:30-15:55 Thomas Oellerich, Goethe University Frankfurt, DE:
Therapeutic strategies revealed by proteogenomics
16:00-16:25 Joseph Schlessinger, Yale University School of Medicine, New Haven, US:
The role of endocrine FGFs in metabolism and cancer
16:30-17:00 Coffee Break (Foyer)
17:00-19:00 Session 8: Targeting the untargetable: Myc and epigenetiv reader domains
Session Chairs: Michael Karin, Lisa Sevenich
17:00-17:25 Martin Eilers, University Würzburg, DE:
MYCN in neuroblastoma: coordinating transcription and DNA replication
17:30-17:55 Laura Soucek, Vall d'Hebron Institute of Oncology, Barcelona, ES:
Inhibiting Myc with Omomyc-derived peptides
18:00-18:25 Stefan Knapp, Goethe University Frankfurt, DE:
Targeting epigenetiv reader domains in cancer
18:30-18:55 Simone Fulda, Goethe University Frankfurt, DE:
Novel opportunities for therapeutic targeting of cell death pathways
19:00 Conference Dinner (Foyer and Terrace First Floor)

 

Registration opens on February 1, 2020.

Registration fee

The participation fee for the Frankfurt Cancer Conference is 180.00 EUR (early-bird registration before April 30, 2020).
From May 1, 2020 on, the fee will be 210.00 EUR.

Registration Date Registration Fee
Early-bird registration February 1 - April 30, 2020 180.00 EUR
Late registration May 1 - August 15, 2020 210.00 EUR

This fee includes: 

  • Access to all conference sessions
  • All conference material (program & abstract book)
  • Welcome Reception on September 23, 2020
  • Coffee breaks and lunches on September 24+25, 2020
  • Conference Dinner on September 24, 2020
  • Free Wi-Fi at conference venue
  • Free public transport in Frankfurt/Main during the conference upon request

Accommodation is NOT included in the registration fee.

Deadlines

Registration

Early-bird registration deadline: April 30, 2020
Registration deadline: August 15, 2020
Payment deadline: August 31, 2020

If the limit of 500 registered participants is reached, registration will be closed.

Registration acknowledgement
Online registration acknowledgements will be sent by automatic email. A final confirmation with details will be sent, if payment is received on time. 

Abstracts

Abstract submission deadline: April 30, 2020

Abstract submission confirmation
Confirmation of abstract submissions will be sent separately by automatic email. After assessment of the abstracts by the Scientific Organizing Committee, authors will receive an email notification and will be informed of acceptance and selection for presentation.

Payment

Please note that your registration will only be complete upon payment of the registration fee! Payment of conference fees can be completed only by SEPA bank transfer in advance. Payment details will be provided via email together with the registration acknowledgement  Please make sure that all bank fees are paid by the participants’ institution. Registration payments are VAT-exempt.

Payment by credit card or cash at the conference is NOT possible! 

As soon as payment has been received on our bank account, an email confirmation will be sent. Should you wish to receive an invoice, please contact uct-events@kgu.de.

Abstract submission starts on February 1, 2020.

Deadline for abstract submission is April 30, 2020.

Conference venue

Goethe University Frankfurt
Campus Westend / Auditorium Complex ("Hörsaalzentrum")
Theodor-W.-Adorno-Platz 1
60323 Frankfurt am Main

Please click on the picture to view or download the conference venue map.


Transport & Directions

The Campus Westend of the Goethe University Frankfurt is well-connected to the international airport of Frankfurt (FRA) and reachable by taxi (20 min) or public transport (35 min).

Deutsche Bahn (www.bahn.de) offers railway services from German and European cities directly to the Frankfurt Hauptbahnhof (Main Station), which is connected to Campus Westend by a 10 min subway ride.

Detailed information on public transportation in Frankfurt: www.rmv.de

Travel by plane
Flight to Frankfurt International Airport (FRA)
Taxi ride to Campus Westend (20 min) or
Public transportation with S8 or S9 to “Hauptwache” and then U1/U2/U3/U8 to “Holzhausenstraße”, 0.5 km walk to Campus Westend

Travel by train
Train ride to “Frankfurt Hauptbahnhof”
Public transportation with S1-9 to “Hauptwache” and then U1/U2/U3/U8 to “Holzhausenstraße”, 0.5 km walk to Campus Westend

Participants can book their train tickets with Deutsche Bahn to Frankfurt am Main at special rates via DB Veranstaltungsticket.

Travel by car
Address for navigation: Theodor-W.-Adorno-Platz 1, 60323 Frankfurt am Main
Parking has to be organized individually, for there are no reserved parking lots at the conference venue. Several parking garages are in immediate vicinity of the conference venue(<1 km):

  • Parkhaus Palmengarten, Siesmayerstraße 61, 60323 Frankfurt am Main
  • Parkhaus Grünhof APCOA, Eschersheimer Landstraße 223, 60320 Frankfurt am Main
  • Parkhaus Turmcenter, Querstraße 7-9, 60547 Frankfurt am Main

Accommodation

Accommodation is NOT included in the registration fee and has to be organized by the participant individually. We have blocked rooms at special rates in hotels in the city center of Frankfurt close to the conference venue. Rooms are available on a first-come-first-serve basis and can be reserved directly via this booking link before 26 August 2020

Booking link (English)               Booking link (German)

Rooms for participants are blocked in the following hotels:

Motel One Frankfurt Römer
Berliner Straße 55
60311 Frankfurt am Main
Distance to conference venue: 2,5 km

Fleming's Express Hotel Frankfurt
Poststraße 8
60329 Frankfurt am Main
Distance to conference venue: 2,3 km

For questions concerning hotel reservations, please contact Ms Steffi Herzog from the Frankfurt Convention Bureau: 
Tel: +49 (0)69 / 2123 0808, Email: s.herzog@infofrankfurt.de
 


Sightseeing

A leaflet containing information on sightseeing attractions in and around Frankfurt as well as a city map can be downloaded here.

The Frankfurt Cancer Conference 2018

The Frankfurt Cancer Conference 2018 was attended by over 400 scientists from all over the world. During the two and a half day conference, a broad spectrum of international speakers presented their cutting-edge science and 140 posters were discussed.

Download full program of 2018 here (PDF)

Browse the picture gallery for an impression of the 2018 Conference!