Clinician Scientist
Dr. med. Christoph Steup
Department of Medicine I – Gastroenterology, Hepatology, Pulmonology, Allergology, Endocrinology, Diabetology
Georg-Speyer-Haus
Research Focus: Targeting the tumour immune microenvironment in colorectal cancer to overcome therapy resistance
Contact: steup@med.uni-frankfurt.de / c.steup@georg-speyer-haus.de
Member of the Greten Lab
As a Clinician Scientist in the research group led by Prof. Greten Dr. Christoph Steup focuses on the cellular and molecular changes within the tumor microenvironment. The tumor microenvironment is composed of tumor cells, fibroblasts, endothelial cells, as well as cells of the innate (macrophages, neutrophils, mast cells, myeloid-derived suppressor cells, dendritic cells, and NK cells) and adaptive immune systems (T and B cells). These cells interact through autocrine and paracrine signaling, maintaining a finely balanced cytokine milieu.
The expression of various immune mediators and the abundance of specific cell types within the tumor microenvironment determine whether tumor-mediated immunosuppression promotes tumor progression or whether anti-tumor immunity predominates, leading to the elimination of cancer cells. A particular focus of Dr. Christoph Steup’s research is the role of alternative pre-mRNA splicing in regulating protein expression and function in gastrointestinal tumor cells.
Find out more about the Greten Lab here.
