Scientists

Junior Group Leader
Dr. Raj Bhayadia

Department of Pediatric and Adolescent Medicine

Research Focus: Patient-derived xenograft models of pediatric AML and preclinical drug testing

Junior Group Leader
Dr. Nadine Flinner

Dr. Senckenberg Institute for Pathology

Research Focus: Digital Pathology

Junior Group Leader
Dr. Katharina Imkeller

Neurological Institute (Edinger Institute)
FCI Immunomonitoring Platform

Research Focus: Computational Immunology

The group of Computational Immunology applies mathematical and computational methods to multi-dimensional immunological and molecular data and thereby seeks to understand inter- and intra-individual heterogeneity of tumor-immune interactions in humans. Its aim is to develop a quantitative and patient-specific understanding of tumor-immune interactions on a cellular and antigen-specific level with the ultimate goal to improve patient care. In its interdisciplinary research the group closely collaborate with experimentalists and clinicians interested in tumor immunology and immunotherapy. Visit the group website for more information on its research and open positions: agimkeller.github.io

 

Junior Group Leader
Dr. Konstantinos Kokkaliaris

Dr. Senckenberg Institute for Pathology

Research Focus: Quantitative Spatial Cancer Biology

Visit the group website for more information on its research and open positions: www.kokkaliarislab.com

Advanced Clinician Scientist
Dr. med. Anjali Cremer

Department of Medicine II, Hematology/Oncology
Max Eder Junior Research Group

Project: Inflammatory signaling via activation of NF-κB is a resistance mechanism to targeted therapy in acute myeloid leukemia (AML)

Advanced Clinician Scientist 
Dr. med. Christine Koch

Department of Medicine I

Project: Immunosuppressive mechanisms in the tumor environment of MSI-high/dMMR gastrointestinal cancer patients treated with immune-checkpoint-inhibitors

Advanced Clinician Scientist 
Dr. med. Anna-Luisa Luger

Dr. Senckenberg Institute of Neurooncology

Project: Redox stress in the glioblastoma microenvironment – implications for therapy resistance and new treatment approaches

Advanced Clinician Scientist 
Dr. med. Patrizia Malkomes

Department of Visceral Surgery

Project: The role of Transglutaminase 2 in tumor progression and its significance as prognostic marker and therapeutic target

Advanced Clinician Scientist 
PD Dr. med. Eva Rettinger

Department of Pediatric and Adolescent Medicine

Project: HER2/ErbB2-chimeric antigen receptor (CAR)-modified lymphocyte-centered immunotherapies for the clinical use in relapsed/refractory (r/r) childhood soft tissue sarcoma (STS)

Clinician Scientist
Dr. med. Katharina Filipski

Neurological Institute (Edinger Institute)
AG Harter

Project: Deciphering the cellular composition of diffuse glioma by use of epigenetic traits

Clinician Scientist
Dr. med. Christian Issing

Department for Ear-, Nose-, Throat Medicine and Georg-Speyer-Haus Institute for Tumor Biology and Experimental Therapy
AG Farin

Project: Patient-derived tumor organoids from head and neck squamous cell carcinoma as a co-clinical research platform

Clinician Scientist
Dr. med. Florestan Koll

Department of Urology and Dr. Senckenberg Institute of Pathology
AG Wild

Project: Molecular and histological subtyping of muscle-invasive bladder cancer

Clinician Scientist
Dr. med. Sebastian Koschade

Department of Medicine II, Hematology/Oncology
AG Brandts

Project: Dissecting the autophagic degradome in FLT3-ITD+ acute myeloid leukemia

Clinician Scientist
PD Dr. med. Henriette Rudolph

Department of Pediatric and Adolescent Medicine

Project: Identification of CNS prone Chimeric Antigen Receptor (CAR) T-Cells in human models of the Blood-Cerebrospinal fluid barrier and the Blood-Brain-Barrier

Clinician Scientist
Dr. med. Katharina Wenger-Alakmeh

Institute of Neuroradiology
AG Hattingen

Project: MR-spectroscopic in vivo metabolic profiling – a novel “omic” in the multi-omics assessment of diffuse large B-cell lymphoma

Clinician Scientist
Dr. med. Sebastian Wolf

Department of Medicine II, Hematology/Oncology
AG Oellerich

Project: Evaluation of mitochondrial metabolism as an innovative and effective treatment target in AML

 

Clinician Scientist
Dr. med. Pia Zeiner

Dr. Senckenberg Institute for Neurooncology
AG Steinbach

Project: Interaction between glioma-associated microglia/macrophages and tumor cells in the context of targeted cancer therapies and immunotherapies

2021/2022

MD Student
Tobias Bexte

Department of Pediatric and Adolescent Medicine, Experimental Immunology
Supervisor: Prof. Dr. Evelyn Ullrich

Project: Entwicklung einer neuen CRISPR/Cas9-basierten NK-Zell-Therapie zur Behandlung unterschiedlicher Krebserkrankungen

MD Student
Daniel Dadra
s
Institute for Experimental Cancer Research in Pediatrics
Supervisor: Dr. Sjoerd van Wijk

Project: Understanding the role of USP22 in MET signalling in rhabdomyosarcoma cell lines

MD Student
Abdallah El Sheikha

Georg-Speyer-Haus Institute for Tumor Biology and Experimental Therapy
Supervisor: Dr. Lisa Sevenich

Project: Auswirkungen der Standardtherapie auf die immunologische Mikroumgebung von Hirnmetastasen und Perspektiven zur Entwicklung neuartiger adjuvanter Therapien

MD Student
Lena Groger

Department of Medicine 2, Hematology/Oncology
Supervisor: PD Dr. Frank Schnütgen

Project: Regulation des pro-apoptotischen Effektorproteins BAX in AML-Zellen nach Venetoclax-Exposition

MD Student
Jessica Rüger

Dr. Senckenberg Institute of Pathology
Supervisor: Prof. Dr. Peter Wild / Dr. Nadine Flinner

Project: Quantitative Determination of NASH Score Components

MD Student
Margaux Schweigert

Institute for Transfusion Medicine and Immunohematology/ DRK Blood Donor Service
Supervisor: Prof. Dr. Halvard Bönig

Project: In vivo Expansion, Phänotypenwandel und Entwicklung von Seneszenz CAR-modifizierter T-Zellen unter kontinuierlicher Antigenexposition

MD Student
Karla Wolf

Department of Medicine 1
Supervisor: Dr. Guido Plotz

Project: Untersuchungen zur Pathogenität unklarer MLH1-Varianten bei Verdacht auf Lynch-Syndrom

2019/2020 - Alumni

MD Student
Ufuk Erdogdu

Institute for Experimental Cancer Research in Pediatrics
Supervisor: Prof. Simone Fulda

Project: Combined inhibition of BET and the antiapoptotic protein BCL-xL as a new treatment strategy for rhabdomyosarcoma

MD Student
Carmen Franiczek

Dr. Senckenberg Institute for Neurooncology
Supervisor: Prof. Joachim Steinbach

Project: Relevance of the cystine/glutamate transporter xCT in glioma cells

MD Student
Veronika Gebel

Institute for Experimental Immunology, Department of Pediatric and Adolescent Medicine
Supervisor: Prof. Evelyn Ullrich

Project: Optimization of viral transduction of CD19-CAR-NK cells for therapy of acute lymphatic leukemia

MD Student
Lea Graafen

Institute for Experimental Immunology, Department of Pediatric and Adolescent Medicine
Supervisor: Prof. Evelyn Ullrich

Project: Functionality of natural killer cells in patients with Ataxia telangiectasia

MD Student
Lea Hermann

Department of Medicine II, Hematology/Oncology
Supervisor: Prof. Christian Brandts

Project: Characterization of the kinase-dependent content of autophagosomes in FLT3-ITD AML by proteomics

MD Student
Sofia Krujatz

Department of Medicine II, Hematology/Oncology
Supervisor: Prof. Hubert Serve

Project: CRIPSR/Cas9-based identification of hypoxia-specific vulnerabilities in AML

MD Student
Anastasia Parmon

Department of Medicine II, Hematology/Oncology
Supervisor: Dr. Frank Schnütgen

Project: Investigation of the mechanisms of the protein IREB2 in AML cells

MD Student
Marius Winkler

Institute for Experimental Cancer Research in Pediatrics
Supervisor: Prof. Simone Fulda

Project: Investigation of cell death mechanisms induced by combined inhibition of oncogenic RAS/MEK/ERK signaling pathway and antiapoptotic MCL-1 protein in rhabdomyosarcoma

The Mildred Scheel Career Center Frankfurt is funded by the German Cancer Aid.