Current Calls

Open PhD Position - Computational Immunology

initially limited to 3 years | Announcement number: 488-2021

The newly established MSNZ Junior Group of Dr. Katharina Imkeller is currently looking for a motivated PhD Student for her research group in “Computational Immunology” within the Edinger Institute (Director: Prof. Karl H. Plate). The research group is embedded in several existing oncology networks that include the University Cancer Center (UCT) Frankfurt-Marburg, the German Consortium for Translational Cancer Research (DKTK) and the Frankfurt Cancer Institute (FCI). The group further closely interacts with the Immunomonitoring Platform of the FCI (Lead: Prof. Karl H. Plate) and the Clinical Translation Platform “Brain Cancers” (Lead: Prof. Joachim Steinbach, Prof. Karl H. Plate, Prof. Winfried Wels).

The group:

  • The research group of “Computational Immunology” is interested in applying mathematical and computational methods to understand therapy induced responses of the immune system. The group develops computational tools and quantitative models for human immunology as well as methodology for immunological and multi-omics data integration for brain tumor patients.

Your project:

  • The planned PhD project focuses on the development of models to study immune responses in patients undergoing immunotherapy and to identify biomarkers that predict resistance to therapy. The research project covers method development and analysis of different types of multi-omics data (single-cell sequencing, proteomics, multiplexed immunofluorescence images) and adaptive immune receptor sequences (B cell and T cell receptors).

Who you are:

  • You have a master´s degree in computational biology, bioinformatics, biophysics or a related field (or a degree in biology/medicine with excellent mathematics and programming skills).
  • You have hands-on experience in programming and data analysis (Python or R).
  • Furthermore, you have a strong interest in immunology and/or cancer biology.
  • You have the ability to conduct independent research and motivation to join an international and interdisciplinary research team.
  • You are fluent in English.
  • Due to legal regulations, a valid proof of measles immunity / measles vaccination is required.

What we offer:

  • Working environment: Interesting collaborative research projects in immunooncology and immunotherapy – State of the art research infrastructure, an inspiring working environment and excellent basic research with translational and clinical applications – Dedicated personal mentoring and participation in training and qualification programs of the MSNZ and the Goethe University.
  • Collective agreement: In addition to an attractive salary based on a collective agreement (65% - E13) with an annual special payment, you benefit from long-term security through company pension schemes
  • Mobility: Free public transport ticket for the State of Hessen
  • Campus: Our attractive university hospital campus offers a modern cafeteria, various cafes, and opportunities
    to rest in numerous green spaces. A walk on the riverside of the Main offers relaxation during breaks
  • Work-Life-Balance: Part-time employment is possible, we offer childcare in our daycare center, child care during holidays, and many attractive offers for health promotion
  • Professional development: Internal and external training for your professional development

Applicants with disabilities are preferred if they have the same personal and professional qualifications.

Join our team!
The research group is looking forward to your application! Use the time until October 8th, 2021 to apply via the career portal. Please state the announcement number and a possible starting date. For further information on the position, please contact Prof. Dr. Karl H. Plate (email: karlheinz.plate@kgu.de).

Universitätsklinikum Frankfurt | Recruiting-Team | Theodor-Stern-Kai 7 | 60590 Frankfurt am Main | bewerbung@kgu.de or application form (please note that we do not return application documents).

The Mildred Scheel Career Center (Mildred-Scheel-Nachwuchszentrum, MSNZ) Frankfurt is a joint institution of the Faculty of Medicine of the Goethe University, the University Hospital Frankfurt, the University Cancer Center (UCT) Frankfurt and the Frankfurt Cancer Institute (FCI). The MSNZ Frankfurt is one of five sites in Germany funded by the German Cancer Aid within the frame of the research program “Mildred-Scheel-Nachwuchszentren”.

The MSNZ offers an excellence program for Medical Scientists (scientists with a life science background or physicians working exclusively in science) aiming at a long-term perspective in university medicine with high scientific expectations.  The MSNZ funds are intended for the scientist's own position and for his or her own scientific projects to support the development into an independent group leader. More information can be found at www.msnz-frankfurt.de. The MSNZ Frankfurt is currently looking for a

Scientist (Postdoc) (f/m/x)
as Medical Scientist focusing on MR-based metabolic imaging (MR spectroscopy, CEST)

full time | with high interest in translational cancer research | initially limited to 3 years | Call no.: 493-2021

The position is offered at the Institute of Neuroradiology (Prof. Dr. Elke Hattingen, Dr. Ulrich Pilatus). Research projects will be conducted primarily at the close-by Brain Imaging Center (BIC), a collaborative research center created by the Goethe University Frankfurt, the Ernst Strüngmann Institute, and the Max-Planck-Institute. The BIC is a place of interdisciplinary research and intellectual exchange with weekly project presentation meetings and discussions.

Project description:

The Institute of Neuroradiology specializes in advanced MR imaging methods to evaluate different biological features related to diagnosis and targeted treatment. While focusing on patients with brain tumors, also neurological disorders are studied. Over the past years, the Institute started to reach out to other oncological subspecialities, transferring expertise to various tumor entities. One important current project aims at adding 1H/31P-MRS in vivo metabolic profiling as a novel molecular level to the multi-omics assessment of lymphoma (superficial lymph nodes) to identify disease subtypes and predictive biomarkers. The successful candidate should participate in this project by implementation and optimization of the required MRS sequences. We are looking for someone dedicated to establishing project specific MRS (and CEST) methods as well as standardized post-processing and data quantification. There will be full support by other researchers of the Institute of Neuroradiology and BIC, including the methodological research group “MR Core Structure” that promotes the creation of novel data acquisition and analysis techniques. While following up on his/her own research interests, the Medical Scientist can get involved in several ongoing translational projects taking advantage of the close interdisciplinary cooperation between the Institute of Neuroradiology, Neurology and Neurosurgery. The Comprehensive Cancer Center Consortium UCT Frankfurt-Marburg is internationally well connected and ensures accessibility of many study patients.

We expect:

  • University degree in medicine or life science or physics and PhD or MD or MD-PhD with outstanding scientific credentials and postdoc experience
  • publications in high-ranking international scientific journals
  • expertise in cancer research and/or MR (especially MRS) imaging technologies
  • a competitive research proposal within the outlined project
  • strong interest in promoting your scientific qualifications and developing into an independent group leader 
  • broad experience in the management of scientific projects
  • high level of motivation and communication skills

Other:

  • Governmental regulations require a valid proof of measles immunity or vaccination

We offer:

  • development of a personal scientific profile with the help of an internal mentor
  • integration into the FCI, the University Cancer Center (UCT) Frankfurt-Marburg and the DKTK
  • access to scientific infrastructure including two state-of-the-art 3T MR scanners with an advanced multi-nuclear Spectroscopy application dedicated for research only at the BIC and in the near future to an additional 7T MRI scanner at the new site of the BIC (Co-BIC)
  • support by the methodological research group “MR Core Structure” at the BIC that promotes the creation of novel data acquisition and analysis techniques 
  • excellent basic research closely linked to translational and clinical aspects in close cooperation with clinical scientists
  • opportunity for a research stay at a national or international research institution
  • participation in further training and qualification programs of the MSNZ such as personal soft skills and career development
  • a diverse and challenging task in an outstanding scientific and international environment
  • the ,,Uni-Strolche‘‘ – our day nursery (reserved places for MSNZ personnel)
  • part-time possibilities (the position is divisible)

Further information on the FCI and its research program can be found at https://fci.health. An overview of the MSNZ is available at www.msnz-frankfurt.com. More information on the Institute of Neuroradiology can be found here, additional information on the Brain Imaging Center (BIC) is available here. For questions on the Institute of Neuroradiology, please contact Prof. Dr. Elke Hattingen (phone: +49 69 6301-5463). For more information on the Brain Imaging Center, please contact Dr. Ulrich Pilatus (phone: +49 69 6301-83822).

Download – Call for Medical Scientists (Neuroradiology)

Download – Application Form

Application

We are looking forward to your application! Please use exclusively the provided application form and submit your request electronically, stating the reference number, together with a letter of motivation by October 15, 2021 via the career portal of the University Hospital Frankfurt.

Applicants with disabilities will be preferred if personal and professional skills are the same.

Selection process

Complete incoming applications will be examined by a selection committee and promising candidates will be invited to a scientific colloquium to present their project proposal and scientific concept to the selection committee. 

Contact for questions

For questions concerning the application process or application form, please contact

Prof. Christian Brandts, phone: + 49 69 6301-87334
or
Dr. Tinka Haydn, phone: +49 69/6301-7251, email: msnz@kgu.de

Contact

Any questions? Please contact us!

 

Dr. Tinka Haydn
University Cancer Center (UCT)
University Hospital Frankfurt
Telefon: +49 (0)69 6301 7251
Fax: +49 (0)69 6301 84689
tinka.haydn@kgu.de
msnz@kgu.de
 

The Mildred Scheel Career Center Frankfurt is funded by the German Cancer Aid.